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Title

Ablation of TRIP-Br2, Encoding a Novel Regulator of Adipocyte Lipolysis, Thermogenesis and Oxidative Metabolism, Prevents Diet-Induced Obesity, Insulin Resistance and Hyperlipidemia

Presented by

Stephen Hsu, M.D., Ph.D.

R. Glenn Davis (DCI) Chair in Clinical and Translational Medicine

Associate Professor of Medicine and Molecular Genetics & Microbiology

Director, MD-PhD Training Program

Co-Director, CTSI TL-1 Pre-Doctoral Training Program

College of Medicine, University of Florida

LEARNING OBJECTIVES:

The participants should be abel to:

• Define and Describe the regulatory pathways that mediate adipocyte lipolysis, mitochondrial oxidative metabolism and adaptive thermogenesis.
• Recognize the important role of gene transcriptional co-repressors as regulators of complex biological processes.
• Compare strategies for pharmacologically mimicking the effect of gene ablation as a therapy for metabolic syndrome.