BOB体育

SPECIAL SEMINAR

Title Leucine-Rich -2-Glycoprotein-1 (Lrg1) Promotes Ocular Neovascularisation Through Modifying TGF Signaling

Presented by John Greenwood, Ph.D. Hugh Davson Professor of Biomedical Research Institute of Phthalmology University College London

**Drinks and sandwiches are provided**

Research into the role the vascular endothelium plays in the pathogenesis of brain and retinal disease is a core component of the laboratory. Work from the Greenwood laboratory has been at the forefront of identifying and characterizing novel endothelial cell mechanisms that facilitate the recruitment of leukocytes to the brain and retina, a critical step in the pathogenesis of diseases such as multiple sclerosis and posterior uveitis. Understanding of these cellular mechanisms remains superficial and ongoing research is aimed at identifying key biochemical pathways that can be targeted through pharmacological intervention.

In recent years considerable effort has also been directed towards identifying novel drivers of vascular pathology in the brain and retina and in particular factors that contribute to the development of neovascularization and vessel remodeling. This work has led to the identification of a number of secreted polypeptides that contribute to angiogenesis/remodeling including one that modifies TGF signaling. This work is currently leading to the development and testing of novel inhibitors that may prevent aberrant vascular development in diseases such as neovascular age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR) where new blood vessel growth is a major cause of vision loss.