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This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other鈥�

Investigator

William Slayton

Status

Accepting Candidates

Ages

3 Years - 29 Years

Sexes

All

This phase III trial investigates the best dose of vinblastine in combination with selumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinib alone in treating children and young adults with low-grade glioma (a common鈥�

Investigator

William Slayton

Status

Accepting Candidates

Ages

2 Years - 25 Years

Sexes

All

This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). Down syndrome patients with鈥�

Investigator

William Slayton

Status

Accepting Candidates

Ages

1 Year - 30 Years

Sexes

All